Using solitary-molecule optical and AFM imaging and power-spectroscopy tactics, we seek out to unravel the mechanistic areas of the structure and dynamics of chromosomes. Our study passions contain:
1996, to start with mesoscopic charge density waves units; and first electrical measurements on only one steel nanocluster concerning nanoelectrodes
Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins
Our get the job done was immediately adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 published their findings on transistors produced from single- and multi-walled carbon nanotubes in Applied Physics Letters.
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Direct immobilization of native yeast iso-one cytochrome c on bare gold: rapidly electron relay to redox enzymes and zeptomole protein-film voltammetry
Considering the fact that 2000 he moved to one-molecule biophysics and nanobiology, with investigation from DNA supercoiling scientific studies of nucleosomes and DNA fix proteins to DNA translocation by nanopores. A short while ago his exploration has focused on studying mobile division with microorganisms on chip, whilst his final fascination is inside the direction of knowing synthetic cells.
He also uncovered time to write down quite a few publications, send out Nearly forty thousand tweets and direct a successful investigation team at Delft University of Know-how. ‘It doesn’t really feel like get the job done’, he says. ‘I’m just terribly curious.’
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But carbon nanotubes have remained a exploration matter of significant curiosity to several. Without a doubt, the outlook on making use of carbon nanotubes to create useful gadgets, in locations which include radio-frequency electronics, electronic electronics and flexible electronics, remains bright.
An integrated microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, initially measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for any new Luttinger description of interacting electrons in nanotubes
Such as, we think about the nucleopore intricate, a gateway among the mobile nucleus plus the cytoplasm. This is an extremely complex system and for that reason tough to research in a cell, so we use biomimetics. We reconstruct holes and then insert unique aspects from the nucleopore elaborate to review transport by it at the single-molecule amount.’
Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij fulfilled enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever design in 2005. (nl)